11 November 2025
: Case report 
Delayed-Onset Rhabdomyolysis of Bilateral Lower Extremities Following Statin Therapy in a 63-Year-Old Woman: A Case Report
Unusual or unexpected effect of treatment, Rare disease, Adverse events of drug therapy
Martin Nguyen
ABDEF 1, Olivia N. Nicoloudakis AEF 1, Patrick M. Farry II AEF 1, Esabelle D. Gervasio AEF 1, Sevar Yaldo AEF 1, Michael Iannetti DEF 2*
DOI: 10.12659/AJCR.948601
Am J Case Rep 2025; 26:e948601
Table 1 Results of autoimmune marker screening.
| Marker | Result* |
|---|---|
| Jo-1 Auto Ab | <0.2 |
| Anti-Jp-1 Ab | <20 |
| Anti-EJ Ab | Negative |
| Anti-Ku Ab | Negative |
| Anti-MDA-5 Ab | <20 |
| Anti-Mi-2 Ab | Negative |
| Anti-NXP-2 Ab | <20 |
| Anti-OJ Ab | Negative |
| Anti-PL-12 Ab | Negative |
| Anti-PL-7 Ab | Negative |
| Anti-PM/Scl-100 Ab | <20 |
| Anti-SAE1 Ab | <20 |
| Anti-SRP Ab | Negative |
| Anti-SS-A 52kD Ab | <20 |
| Anti-TIF-1 gamma Ab | <20 |
| Anti-U1 RNP Ab | <20 |
| Anti-U2 RNP Ab | Negative |
| Anti-U3 RNP Ab | Negative |
| * A negative test result is considered a normal reference value. Ab – antibody; Jo-1 Auto Ab – anti-histidyl-tRNA synthetase antibody; Anti-PL-7 Ab – anti-threonyl-tRNA synthetase antibody; Anti-PL-12 Ab – anti-alanyl-tRNA synthetase antibody; Anti-OJ Ab – anti-isoleucyl-tRNA synthetase antibody; Anti-Jp-1 Ab – anti-asparaginyl-tRNA synthetase antibody; Anti-EJ Ab – anti-glycyl-tRNA synthetase antibody; Anti-MDA-5 Ab – anti-melanoma differentiation-associated gene 5 antibody; Anti-NXP-2 Ab – anti-nuclear matrix protein 2 antibody; Anti-SAE1 Ab – anti-small ubiquitin-like modifier activating enzyme 1 antibody; Anti-SRP Ab – anti-signal recognition particle antibody; Anti-TIF-1 gamma Ab –anti-transcription intermediary factor 1 gamma antibody; RNP – ribonucleoprotein. | |