19 August 2025
: Case report 
Severe Bradyarrhythmia and Reduced Cardiac Output Due to Oral Baclofen Withdrawal in a 24-Year Old Man: A Case Report
Unusual clinical course, Challenging differential diagnosis, Management of emergency care, Clinical situation which can not be reproduced for ethical reasons
Dinuk Sachintha Liyanage
ABCDEF 1*, Jitain Sivarajah BCDEF 1, Craig Johnston BDEF 1, Ravindranath Tiruvoipati BCDEF 1
DOI: 10.12659/AJCR.948678
Am J Case Rep 2025; 26:e948678
Table 1 Timeline of the patient’s clinical course during the hospitalization.
| Day | Key events |
|---|---|
| 1 | Patient arrives in the EDPatient is transferred to the ICU |
| 2 | Dexmedetomidine infusion initiated in the morning with aim to extubateEpisode of severe bradycardia with periods of asystoleDexmedetomidine infusion ceased |
| 5 | Dexmedetomidine infusion initiated in the morning at low dosePatient extubatedPatient requires re-intubation due to ongoing refractory agitationDexmedetomidine ceased after intubation |
| 6 | Ongoing episodes of bradycardia requiring adrenaline infusion |
| 7 | Ongoing episodes of severe bradycardia despite being on no dexmedetomidineBaclofen therapy is reintroducedBradycardic episodes ceased; adrenaline infusion weaned |
| 8 | Successful extubation |
| 9 | Patient discharged from ICU to a general ward |
| 12 | Patient is discharged home |
| ED – Emergency Department; ICU – Intensive Care Unit. | |