09 September 2025
: Case report 
Adverse Dermatological Reaction to Mycophenolate Mofetil in a Patient with Systemic Lupus Erythematosus: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)
Yuxin Cao ABCDEF 1, Haijuan Chen ABCD 2, Zhimei Liao ABC 1, Hui Xiang BCD 1, Xia Zhang BCD 1, Xiaorong Di BCD 1, Wei Tang BCD 3, Li Ding BCD 3, Lianming Liao CDEF 4*DOI: 10.12659/AJCR.948698
Am J Case Rep 2025; 26:e948698
Table 1 Timeline of treatment and symptom evolution.
| Time | Treatment and symptom evolution |
|---|---|
| February 2024 | Cyclosporine dose was reduced to 50 mg every 2 weeks due to high blood pressureTripterygium glycosides 20 mg twice daily was started |
| July 2, 2024 | MMF 0.5 g twice daily was given |
| July 18, 2024 | Fever (39–40°C), chills, and cough appearedOseltamivir and levofloxacin were given and MMF was discontinued |
| July 20, 2024 | Fever subsided |
| July 24, 2024 | MMF 0.75 g was reintroduced twice daily, and methylprednisolone dose was increased |
| July 24, 2024Taking MMF | Nausea, vomiting, fever, and diffuse erythematous rash appearedDiagnosis of drug-induced dermatitis (exanthematous type) was madeLevofloxacin and MMF were discontinued. Intravenous methylprednisolone and antihistamine were given |
| July 26, 2024 | Fever resolved |
| August 1, 2024 | Rash began to fade after 8 days |
| August 2024 | MMF was givenWithin 1 hour, nausea, vomiting, fever, and rash recurrence appeared. Conjunctival edema and congestion appeared the next dayMMF was discontinued |
| August 6, 2024 | Rash resolved |
| MMF– mycophenolate mofetil. | |