15 November 2025
: Case report 
Pravastatin and L-Arginine Use in Early-Onset Severely Growth-Restricted Dichorionic Twins: A Case Report
Unusual clinical course, Unusual or unexpected effect of treatment, Educational Purpose (only if useful for a systematic review or synthesis)
Christina A. Herrera
ABCDEF 1, Neeraj Desai CDE 1, Jessica P. McAlister ABCEF 1, Angelina Avdella DE 1, Stephen J. Carlan CDE 1,2*
DOI: 10.12659/AJCR.948773
Am J Case Rep 2025; 26:e948773
Table 2 Fetal growth progression.
| Intervention | Gestational age | Twin A growth (g, percentile) | Twin B growth (g, percentile) |
|---|---|---|---|
| 19wk3d | 201 g (<1) | 205 g (<1) | |
| Pravastatin and L-arginine initiated | 21wk3d | 274 g (<1) | 283 g (<1) |
| Betamethasone course #1 administered | 24wk0d | ||
| 25wk5d | 454 g (<1) | 470 g (<1) | |
| Betamethasone course #2 administered | 26wk0d | ||
| 27wk3d | 589 g (<1) | 693 g (<1) | |
| 30wk0d | 878 g (<1) | 935 g (<1) | |
| 32wk0d | 1017 g (<1) | 945 g (<1) |