15 October 2025
: Case report 
Gastric Emptying Delay with Pre-Meal Administration of Metformin and Anagliptin in Type 2 Diabetes: Effects on Postprandial Glucose and Triglyceride Levels in a Two-Case Report
Unusual or unexpected effect of treatment
Koichiro Murata
ABCDEFG 1*, Daisuke Sato ABCDEFG 1, Katsutaro Morino ABCDEFG 1,2, Shogo Ida ABCDEFG 1, Natsuko Ohashi ABCDEFG 1, Daisuke Takenaka BCDEF 1, Natsuko Kitagawa BCDEF 1, Mayu Shigemi BCDEF 1, Itsuko Miyazawa ABCDEFG 1, Tsuyoshi Yanagimachi ABCDEFG 1,3, Yukihiro Fujita ABCDEFG 1,3, Hiroshi Maegawa ABCDEFG 1,4, Shinji Kume ABCDEFG 1
DOI: 10.12659/AJCR.948812
Am J Case Rep 2025; 26:e948812
Table 1 Patient characteristics at baseline.
| Characteristic | Patient 1 | Patient 2 |
|---|---|---|
| Sex | Male | Male |
| Age (years) | 62 | 46 |
| Height (cm) | 182 | 164.6 |
| Body mass (kg) | 118.9 | 86.0 |
| Body mass index (kg/m) | 35.9 | 31.7 |
| Duration of diabetes (years) | 17 | 0.08 |
| Diabetic complications | ||
| Retinopathy | None | None |
| Nephropathy6 | Macroalbuminuria | Normoalbuminuria |
| Macroangiopathy | Myocardial infarction | None |
| HbA1c (%) | 7.9 | 10.3 |
| Non-fasting TG (mg/dL) | 254 | 209 |
| HDL-C (mg/dL) | 50 | 36 |
| LDL-C (mg/dL) | 63 | 112 |
| Cr (mg/dL) | 0.86 | 0.94 |
| eGFR (mL/min/1.73 m) | 70.0 | 69.2 |
| Medication | ||
| Glucose-lowering agents | Insulin glargine | Ipragliflozin |
| Glimepiride | ||
| Miglitol | ||
| Ipragliflozin | ||
| Lipid-lowering agents | Rosuvastatin | Rosuvastatin |
| Ethyl icosapentate | ||
| HbA1c – glycated hemoglobin; TG – triglyceride; HDL-C – high-density lipoprotein cholesterol; LDL-C – low-density lipoprotein cholesterol; eGFR – estimated glomerular filtration rate. | ||