Severe Liver Dysfunction Within 48 Hours of Thionamide Therapy in Thyrotoxicosis: A Case Report

30 September 2025 : Case report USA

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment

Christopher Annabi^{ABCDEF 1}, Laila Noor^{ABCDEF 2}, Jamie A. Mullally

^{ABCDEF 2*}

DOI: 10.12659/AJCR.948822

Am J Case Rep 2025; 26:e948822

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Table 2 Liver and thyroid function on admission to our hospital.

	Reference range	Hospital day 4
ALT (U/L)	<55	2728
AST (U/L)	<35	4930
ALP (U/L)	<150	180
Total bilirubin (mg/dL)	<1.3	15.7
TSH (mlU/L)	0.350–4.70	0.002
Free T4 (ng/dL)	0.7–1.9	1.5
Total T3 (ng/dL)	79–149	29.6
AST – aspartate aminotransferase; ALT – alanine aminotransferase; ALP – alkaline phosphatase; TSH – thyroid stimulating hormone; T4 – thyroxine; T3 – triiodothyronine.

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