30 July 2025
: Case report 
Successful Management of Severe Refractory ARDS in Hemophagocytic Lymphohistiocytosis with VV-ECMO: A Case Report and Analysis
Challenging differential diagnosis, Management of emergency care, Rare disease
Mengqi Guan BCDE 1,2, Yan Qian C 3, Zihua Tang F 1,2, Yingya Cao C 1,2,4, Xiaogan Jiang ADG 1,2, Weihua Lu ACG 1,2*, Qiancheng Xu A 1,2,4DOI: 10.12659/AJCR.949154
Am J Case Rep 2025; 26:e949154
Table 1 Key laboratory findings and test results (January 28, 2021 to February 04, 2021).
| Test | Value | Test | Value |
|---|---|---|---|
| White blood cells | 6.21×10/L | Prothrombin time | 15.0 s |
| Hemoglobin | 132 g/L | Activated partial thromboplastin time | 42.9 s |
| Platelets | 80×10/L | Fibrinogen | 6.7 g/L |
| C-reactive protein | 165.7 mg/L | D-dimer | 6.29 ug/mL |
| Procalcitonin | 16.228 ng/mL | ||
| White blood cells | 10.28×10/L | Interleukin-6 | > 4000 pg/mL |
| Hemoglobin | 101 g/L | B-type natriuretic peptide | 2351 pg/mL |
| Platelets | 18×10/L | Intracellular Epstein-Barr virus DNA | 8.99×10 copies |
| C-reactive protein | 190.2 mg/L | Herpes simplex virus type II DNA | Negative |
| Human cytomegalovirus | Negative | ||
| Urea | 13.0 mmol/L | SARS-CoV-2 RNA | Negative |
| Creatinine | 160.0 umol/L | Influenza A antigen testing | Negative |
| Creatine kinase | 187 U/L | T-cell spot test tuberculosis | Negative |
| Creatine kinase Isoenzymes | 63 U/L | Platelet-associated Immunoglobulin G | Negative |
| Troponin | 8.79 ng/mL | Anti-cyclic citrullinated peptide antibody | Negative |
| Total protein | 44.4 g/L | Anti-double-stranded DNA antibody | Negative |
| Albumin | 24.4 g/L | Antineutrophil cytoplasmic antibody | Negative |
| Globulin | 20.00 g/L | Anti-SSA-60 kDa antibody | Negative |
| Prealbumin | 1.5 mg/dL | Anti-Smith antibody | Negative |
| Total bilirubin | 417.65 umol/L | Anti-histidyl-tRNA synthetase antibody | Negative |
| Direct bilirubin | 263.56 umol/L | Anti-PM-Scl antibody | Negative |
| Aspartate aminotransferase | 117 U/L | Anti-Mi-2 antibody | Negative |
| Alanine aminotransferase | 79 U/L | Anti-Ku antibody | Negative |
| Lactate dehydrogenase | 652 U/L | Antinuclear antibody | Negative |