Pharmacological Intervention for Refractory Biofilm Infection After Hemipelvic Replacement Surgery: Multidisciplinary Management of a Case of Giant Cell Tumor of Bone

26 November 2025 : Case report China

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment

Liling Huang^{BE 1,2}, Linyu Wang

^{ACF 1*}, Hao Nong^{BC 1,2}, Bin Liu^{A 3}, Yan Li^{AF 3}

DOI: 10.12659/AJCR.949210

Am J Case Rep 2025; 26:e949210

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Table 1 Results of drainage fluid culture and drug susceptibility testing.

Bacteria	Antibiotic	MIC	Sensitivity
	Amikacin	≤8
	Amoxicillin/clavulanic acid	>4/2	Resistant
	Ampicillin	>8	Resistant
	Cefoxitin	>8
	Ciprofloxacin	4	Resistant
	Clindamycin	≤0.5	Sensitive
	Fusidic acid	≤1
	Gentamicin	≤1	Sensitive
	Gentamicin screening test	≤500
	Linezolid	1	Sensitive
	Nitrofurantoin	≤16	Sensitive
	Oxacillin	>2	Resistant
	Penicillin	>0.25	Resistant
	Quinupristin/dalfopristin	≤0.5
	Rifampicin	≤0.5	Sensitive
	Teicoplanin	≤1	Sensitive
	Tetracycline	2	Sensitive
	Tobramycin	≤2
	Trimethoprim	>2
	Sulfamethoxazole/trimethoprim	>4/76	Resistant
	Vancomycin	2	Sensitive
	Erythromycin	≤0.25	Sensitive
	Mupirocin – high level	>256	Resistant
	Mupirocin	>4	Resistant
MIC – minimum inhibitory concentration.

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