29 September 2025
: Case report 
Complex Ocular Adverse Events Following Oxaliplatin Treatment: A Case Report
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Unexpected drug reaction, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Chao-Yang Zhao ABCEF 1, Chang-Sheng Liao BCF 2, Zi-You Yuan BE 1, Chen-Yue Zhao EF 3, Shao-Feng Hao
E 1, Hui-Lin Li ABD 1*
DOI: 10.12659/AJCR.949346
Am J Case Rep 2025; 26:e949346
Table 1 Diagnosis and treatment tracking form for oxaliplatin (OXA) chemotherapy-related ocular complications.
| No. | Date | Drugs | Cycle | Symptoms | Key examination findings | Treatment | Surgery/special interventions |
|---|---|---|---|---|---|---|---|
| 1 | 4 Mar 2024 | – | – | Normal vision | – | Radical gastrectomy + D2 dissection | Initial surgery |
| 2 | 7 Apr 2024 | OXA + S-1 | 1 | – | – | Chemotherapy initiated | – |
| 3 | 3 May 2024 | OXA + S-1 | 2 | – | – | Continued chemotherapy | – |
| 4 | 18 May 2024 | – | – | Acute vision loss | Right eye (RE): 0.1, left eye (LE): counting fingers (CF) at 1 ft; iris cysts, retinal detachment | Oral prednisone (irregular) | – |
| 5 | 30 May 2024 | OXA + S-1 | 3 | – | – | Cycle 3 completed | – |
| 8 | 9 Aug 2024 | – | – | – | Vision: hand motion at 1 ft; cataract; elevated aqueous IL-6 | – | Right eye phacoemulsification |
| 9 | 23 Aug 2024 | – | – | – | – | – | Left eye phacoemulsification and cyst biopsy |
| 11 | 9 Sep 2024 | – | – | Vision improved | RE: CF at 30 cm (corrected 0.5); LE: CF at 30 cm (0.3); retinal detachment improved | – | – |
| 16 | 27 Nov 2024 | Sintilimab | – | Recurrent vision decline | RE: CF at 20 cm (0.4); LE: CF at 20 cm (0.2); persistent cysts, retinal detachment | – | – |
| 17 | 28 Nov 2024 | OXA + S-1 | 9 | – | – | Cycle 9 resumed | – |