Platypnea-Orthodeoxia Syndrome Associated With a Right-to-Left Cardiac Shunt Detected by Lung Perfusion Scintigraphy

23 December 2025 : Case report Japan

Challenging differential diagnosis, Rare disease

Yusuke Nakano

^{ABCDEFG 1,2*}, Hirohiko Ando^{CDE 1}, Akinori Satake^{DE 3}, Reiji Goto^{DE 1}, Kentaro Mukai^{DE 1}, Tetsuya Amano^{CDE 1}

DOI: 10.12659/AJCR.949642

Am J Case Rep 2025; 26:e949642

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Table 2 Oxygen saturation and right and left atrial pressures in various postures.

Posture	Right lateral	Supine	Left lateral	Semi-sitting
SpO, %	82	91	89	80
Mean PAP, mmHg	N/A	17.0	N/A	N/A
PVR, dyne·s·cm	N/A	124	N/A	N/A
Qp/Qs	N/A	0.61	N/A	N/A
RAP, mmHg	14/10/9	12/9/8	10/7/6	N/A
LAP, mmHg	10/9/8	11/8/7	12/9/8	N/A
PAP – pulmonary arterial pressure; PVR – pulmonary vascular resistance; Qp/Qs – pulmonary-to-systemic blood flow ratio; RAP – right atrial pressure; LAP – left atrial pressure; N/A – not available.

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