19 November 2025
: Case report 
Recombinant Factor VIIa Prophylaxis in 2 Brothers with Bernard-Soulier Syndrome
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Unusual setting of medical care, Rare disease
Eman Almatar AC 1*, Sondus Alsharidah
AC 1, Omnia A. Hashem BE 1
DOI: 10.12659/AJCR.949654
Am J Case Rep 2025; 26:e949654
Table 1 Case 1 and Case 2 comparison.
| Case 1 | Case 2 | |
|---|---|---|
| 1 Age at diagnosis | 2 years | 6 weeks |
| 2 Bleeding type | Gingival bleeding | Epistaxis |
| 3 Bleeding frequency | 3–4 times per week | Weekly |
| 4 Bleeding time | >6 min | >8 min |
| 5 rFVIIa dose | 4.5 mg | 4 mg |
| 6 Platelet transfusions | 3–4 times per year | 2–4 times per year |
| 7 Follow-up | 18 weeks | 24 weeks |