18 October 2025
: Case report 
The Role of Laparoscopy in Diffuse Large B-Cell Lymphoma with High 18F-Fluorodeoxyglucose Uptake Lymph Node in the Retroperitoneum After Chemotherapy
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment
Xingnan Wu ABCDE 1, Tianzhe Gao BCF 1, Yongqiang Si BCF 1, Chiyu He BCDF 1, Kankai Zhu AB 1, Yang Dong AB 1, Xiaodong Wang AB 1, Xiaosun Liu ABCDEG 1*DOI: 10.12659/AJCR.949741
Am J Case Rep 2025; 26:e949741
Table 1 Clinical features of patients who underwent laparoscopic surgery and lymph node biopsy.
| Patient no. | Age (yrs) | Sex | Stage | Chemotherapy regimen | Pathology type | Operative time | Number of lymph nodes retrieved and tumor activity of postoperative specimens | Therapy after surgery | Duration of follow-up(yrs) and outcome | Surgical complications |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 37 | M | II | 8 cycles of R-CHOP | DLBCL, GCB | 1h 51min | 6(−) | None | 2, alive, NED | (−) |
| 2 | 65 | M | III | 6 cycles of R-CHOP, 2 cycles of rituximab, 2 cycles of CHOP-E, 1 cycle of RGDP | DLBCL, GCB | 2h 32min | 3(−) | None | 2, alive, NED | (−) |
| 3 | 61 | M | III | 4 cycles of R-CHOP, 4 cycles of R-CHOP+ zebutinib | DLBCL, non-GCB | 2h 47min | 1(−) | Lenalidomide for 6 months | 2.5, alive, NED | (−) |
| 4 | 65 | M | III | 6 cycles of R-CHOP | DLBCL, GCB | 54min | 1(−) | 4 cycles of R-GemOxD | 2, alive, NED | (−) |
| 5 | 56 | F | II | 6 cycles of R-CHOP, 2 cycles of rituximab | DLBCL, non-GCB | 49min | 1(+) | 4 cycles of R-GemOxD | 1.5, alive, with disease | (−) |
| M – male; F – female; h – hour; min – minute; R-CHOP – rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone; CHOP-E – cyclophosphamide, vincaleukoblastine, epirubicin, dexamethasone, etoposide; R-GemOxD – rituximab, gemcitabine, oxaliplatin, dexamethasone; RGDP – rituximab, gemcitabine, cisplatin, dexamethasone; (−) – negative; (+) – positive; NED – no evidence of disease. | ||||||||||