29 October 2025
: Case report 
Gastric Adenocarcinoma Resembling Submucosal Tumor: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Rare disease
Hongli Liu ABDE 1, Chao Deng EF 1, Rui Song DE 1, Juan Li BF 1, Song He AE 1, Zhihang Zhou F 1, Suhua Wu F 1, Hongdan Cao E 2, Lin Lv
ADE 1*
DOI: 10.12659/AJCR.949785
Am J Case Rep 2025; 26:e949785
Table 1 Previous case reports of gastric cancer with features of submucosal tumor.
| Author | Sex | Age | Clinical presentation | Diagnosis | Diagnostic method | Surgery |
|---|---|---|---|---|---|---|
| Umehara []2 | Male | 50 | Hematemesis | Poorly differentiated adenocarcinoma | Endoscopic biopsy | TG |
| Ohara []4 | Male | 48 | Epigastric discomfort | Well differentiated adenocarcinoma | Postoperative biopsy | SG |
| Kume []5 | Female | 49 | Epigastric pain | Well differentiated adenocarcinoma | EMR | SG |
| Fujiyoshi []6 | Female | 73 | Routine health evaluation | Moderated differentiated adenocarcinoma | Endoscopic biopsy | PG |
| Takahashi []7 | Male | 50 | Routine health evaluation | LELC | Laparoscopic biopsy | DG |
| Teraishi []8 | Male | 63 | Routine health evaluation | Poorly differentiated adenocarcinoma | Endoscopic biopsy | DG |
| Ando []9 | Female | 65 | Anemia and tarry stools | MUC | Laparoscopic biopsy | SG |
| Kim []10 | Male | 66 | Dysphagia | MUC | Endoscopic biopsy | TG |
| Matsumoto []11 | Male | 58 | Routine health evaluation | Poorly differentiated adenocarcinoma | ESD | Not described |
| Yoo []12 | Female | 40 | Routine health evaluation | Signet ring carcinoma | Endoscopic biopsy | TG |
| Yu []13 | Female | 54 | Dyspepsia, vomiting | MUC | Laparoscopic biopsy | none |
| Yu []13 | Female | 50 | Routine health evaluation | MUC | Postoperative biopsy | TG |
| Li []14 | Male | 44 | Paroxysmal epigastric pain | Poorly differentiated adenocarcinoma | ESD | TG |
| Cha []15 | Male | 69 | Routine health evaluation | Poorly differentiated adenocarcinoma | Endoscopic biopsy | TG |
| Yamane []16 | Male | 81 | Routine health evaluation | Poorly differentiated adenocarcinoma | EUS-FNA and boring biopsy | DG |
| Lee []17 | Female | 64 | Routine health evaluation | Signet ring carcinoma | Laparoscopic biopsy | SG |
| Suenaga []18 | Male | 70 | Routine health evaluation | Well-differentiated adenocarcinoma | ESD | Laparoscopic TG |
| Wada []19 | Male | 65 | Routine health evaluation | Poorly differentiated adenocarcinoma | Endoscopic biopsy | Laparoscopic SG |
| Imamura T []20 | Male | 66 | Not described | Well-differentiated adenocarcinoma | Laparoscopic biopsy | Laparoscopic PG |
| Chen []21 | Male | 50 | Epigastric discomfort and hematochezia | LELC | ESD | TG |
| Present case | Male | 60 | Stomach discomfort | Poorly differentiated adenocarcinoma | ESD | SG |
| LELC – lymphoepithelioma-like carcinoma; MUC – mucinous carcinoma; EMR – endoscopic mucosal resection; ESD – endoscopic submucosal dissection; EUS-FNA – endoscopic ultrasonography-guided fine needle aspiration middle; SG – subtotal gastrectomy; TG – total gastrectomy; PG – proximal gastrectomy. | ||||||