22 September 2025
: Case report 
Initial Manic Presentation in Creutzfeldt-Jakob Disease: A Case Report
Challenging differential diagnosis, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Fatima Ghazi Alotaibi
ABCDEF 1*, Rakan Bahammam ABCDEF 1, Khalid M. Alqarni ABCDEF 1, Othman O. Aldraihem E 2
DOI: 10.12659/AJCR.949905
Am J Case Rep 2025; 26:e949905
Table 3 Infectious work-up.
| Result | Reference range | |
|---|---|---|
| Brucella culture | Negative | – |
| Acid-fast bacilli culture | Negative | – |
| Cryptococcus antigen | Negative | – |
| Hepatitis B surface antigen | Negative | – |
| Hepatitis B core antibody | Negative | – |
| Hepatitis B surface antibody | 2 mIU/mL | <10 IU/L |
| Hepatitis C antibody | Negative | – |
| HIV 1&2 Ag/Ab | Negative | – |
| HSV 1/2 PCR | Negative | – |
| Syphilis antibodies | 0.10 COI | <1.00 COI |