28 September 2025
: Case report 
Prosthetic Knee Joint Infection with Haemophilus influenzae 1 Year After Total Knee Arthroplasty: A Case Report and Literature Review
Unusual clinical course, Challenging differential diagnosis, Educational Purpose (only if useful for a systematic review or synthesis)
Ahmed AlSharakhat
ABDEF 1, Safiya AlMusawi ABDEF 2*, Ahmed Husain BD 3, Wafa Hasan BD 4, Nisha Chandran Vijayamma BD 1, Feras AlMarzooq ABDEF 3
DOI: 10.12659/AJCR.950298
Am J Case Rep 2025; 26:e950298
Table 1 Summary of the reported cases of prosthetic joint infection caused by Haemophilus influenzae (1985–2023).
| Author [reference] | Country | Age (years)/sex | Presen-tation | Time after arthroplasty | H. influenzae type | Risk factor(s) | Treatment | Outcome |
|---|---|---|---|---|---|---|---|---|
| Limbird TJ, 1985[]6 | USA | 63/ female | Low-grade fever and left hip pain | 6 months | NA | Flu-like illness before 3 weeks | NED at 1 year | |
| Borenstein & Simon, 1986[]7 | USA | 25/ female | Left hip pain | 3 years | Non-typeable | Ambulating with a walker | ||
| Bezwada et al, 2002[]8 | USA | 43/ female | Left knee pain, swelling, fever, and chills | 3 years | NA | NED | ||
| Khan & Reddy, 2013[]3 | UK | 71/ male | 10 years | Non-typeable | NED at 6 months | |||
| Quellec et al, 2013[]9 | France | 66/ female | Fever and right hip pain | NA | Biotype II, non-typeable | NED | ||
| Söderquist, 2014[]10 | Sweden | 25/ female | Right hip pain | NA | Biotype III, non-typeable | NED | ||
| Sermet et al, 2021[]11 | France | 79/ female | Fever and right hip pain | 10 years | Non-typeable | NED | ||
| Weenders et al, 2023[]5 | Germany | 60/ female | Left knee pain | NA | Non-typeable | NED after 6 months | ||
| CLL – chronic lymphatic leukemia; COPD – chronic obstructive pulmonary disease; IV – intravenous; NA – not available; NED – no evidence of disease; SLE – systemic lupus erythematosus; USA – United States of America; UK – United Kingdom. | ||||||||