30 November 2025
: Case report 
Afebrile HSV-2 Encephalitis with Radiographic Atypia and Minimal Systemic Inflammation: A Case Report
Unusual clinical course, Challenging differential diagnosis
Shunsuke Kondo
ABDEF 1*, Wejdan Abo Qayas EF 2, Osama Hasan EF 1, Rachel Haide N. Tacata E 3, Matthew W. Kobylinski EF 1, Lorrance Majewski E 4
DOI: 10.12659/AJCR.950444
Am J Case Rep 2025; 26:e950444
Table 2 Cerebrospinal fluid analysis.
| WBC | 58 | /mm | Haemophilus influenzae | − |
| Neu | 3.0 | % | HSV-1 | − |
| Lym | 95 | % | HSV-2 | + |
| Mono | 2.0 | % | HHV-6 | − |
| RBC | 283 | /mm | HPeV | − |
| Protein | 174 | mg/dL | − | |
| Glucose | 39 | mg/dL | spp. | − |
| − | ||||
| Oligoclonal band | − | − | ||
| Opening pressure | 30 | cmHO | Varicella | − |
| Cryptococcus | − | |||
| WBC – white blood cells; Neu – neutrophils; Lym – lymphocytes; Mono – monocytes; RBC – red blood cells; HSV – herpes simplex virus; HHV – human herpesvirus; HPeV – human parechovirus. | ||||