18 November 2025
: Case report 
Primary Cutaneous Cribriform Tumor with Clinical and Histological Diagnostic Challenges: Case Report and Literature Review of a Rare Skin Neoplasm
Challenging differential diagnosis, Rare disease
Wassim Hamadeh
AEF 1*, Elie Berbery AEF 2, Mohammad H. Abbas ABE 1, Racil Allaw ABD 3, Bassam F. Matar AEF 3
DOI: 10.12659/AJCR.950487
Am J Case Rep 2025; 26:e950487
Table 1 Published cases of cribriform tumor with clinical and pathological features, management, and outcomes.
| Reference (Year) | Patient age/sex | Lesion site | Lesion size | Treatment | Follow-up duration | Outcome | Notes |
|---|---|---|---|---|---|---|---|
| Rütten et al (2009) | Median approx. 48, mostly F (n=26) | Extremities (most common) | 4–12 mm (most) | Wide local excision | Up to 3 years | No recurrence/metastasis | Largest cohort; female predominance (19/26) |
| Arps et al (2015) | 40–65, M/F (n=6) | Arms, legs | 4–12 mm | Local excision | Not reported | No recurrence/metastasis | Expanded clinicopathologic spectrum |
| Boettler et al (2021) | 61/F | Back | Approx. 20 mm | Wide local excision | Not reported | No recurrence | Emphasizes indolent course |
| Lee et al (2021) | 33/M | Knee (leg) | Approx. 20 mm | Wide local excision ± Mohs | Not reported | No recurrence | Youngest male reported with large lesion |
| Present case (2025) | 33/M | Left leg | 20 mm | Wide local excision | 2 months | No recurrence | Younger male, large extremity lesion; adds to spectrum |