25 January 2026
: Case report 
Gastroduodenal Intussusception With Gastric Outlet Obstruction and Periampullary Compression Due to a Gastrointestinal Stromal Tumor in the Stomach
Unusual clinical course, Challenging differential diagnosis, Management of emergency care, Clinical situation which can not be reproduced for ethical reasons
Soumyadip Sain
ABDEF 1, Vidit A. Dholakia BDEF 1*, Suvendu Sekhar Jena ACEF 1, Amitabh Yadav F 1, Samiran Nundy EF 1
DOI: 10.12659/AJCR.950627
Am J Case Rep 2026; 27:e950627
Table 1 Previously reported cases of gastroduodenal intussusception due to gastric GIST*.
| Reference (Authors) | Year | Age/Sex | Diagnosis | Management | Size (cm) | Location |
|---|---|---|---|---|---|---|
| Crowther et al []3 | 2002 | 59/F | GIST with epigastric pain, vomiting | Partial gastrectomy | 6 | Anterior wall of antrum |
| Samamé et al []17 | 2007 | NA | GIST with intussusception | NA | NA | NA |
| Shum et al []18 | 2007 | 34/F | GIST with intermittent epigastric pain | Partial gastrectomy | 5×5 | Fundus |
| Adjepong et al []10 | 2007 | 84/M | GIST with gastroduodenal intussusception | Laparoscopic Billroth II resection | 4×3 | Gastric antrum |
| Siam and Siow []19 | 2008 | 29/M | GIST with intermittent vomiting, melena | Billroth I partial gastrectomy | 6×6 | Antrum |
| Chan et al []20 | 2009 | 34/F | GIST with epigastric pain | Laparoscopic wedge resection | 6.5×4.4×3.8 | Posterior wall of fundus |
| Gyedu et al []21 | 2011 | 59/F | GIST with intussusception | Partial gastrectomy | 7×6×5 | Anterior wall of stomach |
| Seok et al []22 | 2012 | 51/M | GIST with intussusception | Gastric partial resection | 5.5×4.2 | Posterior wall of stomach |
| Basir et al []23 | 2012 | 62/F | GIST with gastric outlet obstruction | Billroth II partial gastrectomy | 5.2×3.5 | Gastric body |
| Wilson et al []24 | 2012 | 78/F | GIST with vomiting | Laparoscopic wedge resection | 4.4×3.3×3.4 | Antrum |
| Rittenhouse et al []25 | 2013 | 52/F | GIST with epigastric pain | Laparoscopic wedge resection | 5×5 | Fundus |
| Babannavar et al []26 | 2015 | 74/M | GIST with gastroduodenal intussusception | Partial gastrectomy | NA | Gastric antrum |
| Indiran et al []27 | 2015 | NA | GIST with gastroduodenal intussusception | NA | NA | NA |
| Komatsubara et al []28 | 2016 | 90/F | GIST with loss of appetite | Wedge resection | 5×4.5×4 | Fundus |
| Yildiz et al []8 | 2016 | 85/F | GIST with gastroduodenal intussusception | Subtotal gastrectomy | 6×5 | Antrum |
| Jameel et al []29 | 2017 | 65/F | Gastric GIST causing intussusception | Wedge resection via gastrotomy | 6×6×4 | Posterior wall of antrum |
| Yamauchi et al []15 | 2017 | 95/F | GIST with melena | Endoscopic submucosal dissection | 4.2×3.9 | Distal body |
| Zhou et al []30 | 2018 | 69/M | Acute abdomen due to GIST | Wedge resection | 4.5×4 | Posterior wall of antrum |
| Ssentongo et al []31 | 2018 | 85/F | GIST with melena, postprandial vomiting | Wedge resection | 2.5×2.5 | Fundus |
| De and Basu []32 | 2018 | 42/F | GIST with abdominal pain | Wedge resection | 8×7×4 | Anterior wall of antrum |
| Đokić et al []7 | 2019 | 62/M | GIST of lesser curvature | Open resection | 7.5×5.5×4 | Lesser curvature, gastric body |
| Hsieh et al []6 | 2021 | 84/F | GIST with intussusception | Endoscopic submucosal dissection | 5.9 | Duodenal bulb (invaginated) |
| Zhang et al []5 | 2022 | 85/M | GIST with upper GI bleed | Laparoscopic exploration and excision | 5×3.5 | Gastric antrum |
| Present case | 2025 | 71/F | GIST with intussusception and jaundice | Excision via gastrotomy | 5.5×2.2×1.8 | Anterior wall of antrum |
| F – Female; GI – gastrointestinal; GIST – gastrointestinal stromal tumor; M – Male; NA – information not available in cited article. * Data in this table were obtained through a structured literature search in PubMed and Google Scholar regarding the period from January 1990 to December 2024, using the following search terms: “gastroduodenal intussusception”, “gastric GIST”, “gastrointestinal stromal tumor intussusception”, “gastric tumor prolapse”, and “gastric outlet obstruction GIST”. Only English-language case reports and case series involving gastroduodenal intussusception secondary to gastric GIST were included. Duplicate reports and cases of intussusception unrelated to gastric GIST were excluded. | ||||||