26 December 2025
: Case report 
Primary Well-Differentiated Neuroendocrine Tumor of the Breast: A Case Report and Literature Review
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Patient complains / malpractice, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis), Rare coexistence of disease or pathology
Sanjna Sai Gudena DEF 1*, Nilesh Digvijay Kashikar E 2, Matthew Charles Wakefield E 3DOI: 10.12659/AJCR.950684
Am J Case Rep 2025; 26:e950684
Table 2 Additional studies.
| Source | Sample size | Results/findings |
|---|---|---|
| Mod Pathol []15 | 43 | Favorable prognosis: Low grade, ER/PR(+), mucinous differentiation |
| Breast []16 | 12 | Synaptophysin 11/12, Chromogranin 5/12 |
| Int J Surg []8 | 13 NEC, 22 IDC-NE, 35 IDC, 35 ILC | Recurrence: 0/13 NEC, 2/22 IDC-NE, 6/35 IDC, 7/35 ILC |
| Hum Pathol []17 | 334 | Synaptophysin, Chromogranin A associated with improved OS (=0.043, 0.03) |
| Oncol Rep []18 | 7 | Axillary LN+: 3/7; ER/PR(+)/HER2(−): 7/7; Chemo/Radiation: 4/7; Anti-estrogen: 7/7; Deaths: 0/7 |