22 April 2026
: Case report 
Diagnostic Approaches to Adult Cystic Nephroma: Insights From Two Cases
Challenging differential diagnosis, Rare disease
Madalina Bosoteanu AE 1,2, Raluca Ioana Vodă EF 3,4*, Cristian Ionut Orășanu
EF 1,4, Luana-Andreea Nurla EF 5, Nicolae Ciufu BE 6,7
DOI: 10.12659/AJCR.950808
Am J Case Rep 2026; 27:e950808
Table 1 Immunohistochemical evaluation of the cystic renal lesion in case 1.
| Antibody (clone) | Results |
|---|---|
| ER (SP1) | Positive nuclear staining in stromal structures |
| PR (SP2) | Positive nuclear staining in stromal structures |
| CK7 (BC-1) | Positive in cystic epithelial cells and septal tubular/microcystic structures |
| PAX8 (BC12) | Diffusely positive in cystic epithelial cells and septal tubular/microcystic structures |
| Melan A (A103) | Negative |
| Ki-67 (SP6) | Positive in 2% of tumor cells |
| CK7 – cytokeratin 7; ER – estrogen receptor; Melan-A – melanoma antigen A; PAX8 – paired box gene 8; PR – progesterone receptor. | |