19 January 2026
: Case report 
Diagnosis of Dual c- and p-ANCA Vasculitis Following SARS-CoV-2 Infection: A Case Report
Rare disease
Isaac B. Wolfkind
ABDEF 1, Ronan J. McOsker ABDEF 1, Debra Karling ADEF 1, Connor McKinney ABDE 2, Eslam Mohamed ADEFG 1,3*
DOI: 10.12659/AJCR.950958
Am J Case Rep 2026; 27:e950958
Table 1 Laboratory results at the time of vasculitis diagnosis. Standard ranges are from the January 2025 American Board of Internal Medicine guidelines and are adjusted for an adult female where applicable [46]. ANCA and anti-GBM standard ranges were not included in the guidelines and were thus provided by the hospital’s laboratory.
| Laboratory parameter | Recorded value | Standard range |
|---|---|---|
| Leukocytes (K/μ) | 9.6 | 4.0–11 |
| Erythrocytes (million/μL) | 2.91 | 4.2–5.9 |
| Hemoglobin (g/dL) | 7.4 | 12–16 |
| Hematocrit (%) | 22.7 | 37–47 |
| Mean corpuscular volume (fL) | 78.1 | 80–98 |
| Red cell distribution width (%) | 19.2 | 9.0–14.5 |
| Platelet count (K/μL) | 306 | 150–450 |
| Sodium (mEq/L) | 132 | 136–145 |
| Potassium (mEq/L) | 4.3 | 3.5–5 |
| Chloride (mEq/L) | 109 | 98–106 |
| Glucose (mg/dL) | 87 | 70–99 |
| Blood urea nitrogen (mg/dL) | 73 | 8–20 |
| Creatinine (mg/dL) | 5.80 | 0.50–1.10 |
| Estimated glomerular filtration rate (mL/min/1.73 m) | 7 | 90–120 |
| Alpha-1-antitrypsin (mg/dL) | 760 | 150–350 |
| Angiotensin-converting enzyme (U/L) | 33 | 8–53 |
| Kappa free light chains (mg/L) | 403.20 | 3.3–19.4 |
| Lambda free light chains (mg/L) | 353.90 | 5.7–26.3 |
| ANCA indirect immunofluorescence assay titer | >1: 1280 | Negative |
| Anti-myeloperoxidase antibody (AU/mL) | 202 | <1 |
| Anti-serine protease 3 antibody (AU/mL) | 38 | <1 |
| Anti-nuclear IgG ELISA titer | Negative | <1: 40 |
| Anti-GBM IgG multiplex bead assay (AU/mL) | Negative | <1 |
| Complement component C3 (mg/dL) | 115 | 100–233 |
| Complement component C4 (mg/dL) | 27 | 14–48 |