Co-Pathogenic Role of BRCA1 and OBSCN Deletions in Chinese Familial Breast Cancer: A Case Report

Lili Yi; Kexin Chen; Dandan Wang; Ruhao Wang; Xiaoru Zhu; Jian Chai; Xiaodong Jia; Fei Xu; Mingliang Gu; Chuanyou Cui; Wei Zhang

doi:10.12659/AJCR.951196

02 May 2026 : Case report China

Co-Pathogenic Role of BRCA1 and OBSCN Deletions in Chinese Familial Breast Cancer: A Case Report

Unknown etiology

Lili Yi^{BCDE 1}, Kexin Chen^{CEF 1}, Dandan Wang^{C 2}, Ruhao Wang^{D 1}, Xiaoru Zhu^{C 2}, Jian Chai^{G 1}, Xiaodong Jia^{CD 1}, Fei Xu^{DG 3}, Mingliang Gu^{AG 1}, Chuanyou Cui^{BE 4*}, Wei Zhang^{ADE 5}

DOI: 10.12659/AJCR.951196

Am J Case Rep 2026; 27:e951196

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Table 1 SNPs exhibiting significantly different allele frequencies.

Chr	SNPs	AAChange.refGene	Primer
1	NM_001386125.1	c.18523+2_18523+3delTG	F: TGGGTATCCTGTGAGCTTTGACTR: GGATTTGGGGCCTCACTGTC
5	NM_001142556.2	c.978del: p.Phe326Leufs*54	F: TGGGAGTCCAGGTTTCTCAGTCR: ACATTTCCCTATGTCTCTGAACACCT
17	NM_007294.4	c.5521del: p.Ser1841Valfs*2	F: GAGCCTAGTCCAGGAGAATGAAR: CCTTCTACTGTCCTGGCTACTAAA

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Co-Pathogenic Role of BRCA1 and OBSCN Deletions in Chinese Familial Breast Cancer: A Case Report

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