02 May 2026
: Case report 
Co-Pathogenic Role of BRCA1 and OBSCN Deletions in Chinese Familial Breast Cancer: A Case Report
Unknown etiology
Lili Yi BCDE 1, Kexin Chen CEF 1, Dandan Wang C 2, Ruhao Wang D 1, Xiaoru Zhu C 2, Jian Chai G 1, Xiaodong Jia CD 1, Fei Xu DG 3, Mingliang Gu AG 1, Chuanyou Cui BE 4*, Wei Zhang ADE 5DOI: 10.12659/AJCR.951196
Am J Case Rep 2026; 27:e951196
Table 2 Presentation of pathogenic gene results in the samples.
| ID | BRCA1 | HMMR | OBSCN |
|---|---|---|---|
| II-2 | LOH | – | – |
| II-3 | – | – | LOH |
| II-6 | – | LOH | – |
| III-8 | LOH | – | LOH |
| III-10 | – | LOH | – |
| III-13 | LOH | – | LOH |
| III-14 | LOH | LOH | LOH |
| III-16 | – | – | LOH |
| LOH – heterozygosity. | |||