18 April 2026
: Case report 
Prenatal Diagnosis of Renal Cysts and Diabetes Syndrome (RCAD): A Case Report
Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Congenital defects / diseases, Clinical situation which can not be reproduced for ethical reasons
Maisa Manasar-Dyrbuś
ABDEF 1, Rafał Stojko E 1, Monika Paul-Samojedny DEF 2, Ewa Winkowska DF 1, Jakub Staniczek ABDEF 1*
DOI: 10.12659/AJCR.951250
Am J Case Rep 2026; 27:e951250
Table 1 Timeline.
| 13+4 weeks | First-trimester combined screening – no structural anomalies. Intermediate risk for trisomy 21. Patient declined NIPT/amniocentesis |
| 18+0 weeks | Patient presented to the ED with abdominal pain and shortness of breath. No amniotic fluid leakage; US: oligohydramnios, bilateral renal anomalies |
| 19+0 weeks | Hospital admission for amnioinfusion and anatomical assessment. Amnioinfusion performed (200 mL warmed saline) – procedure interrupted due to abdominal pain |
| 19+1 weeks | Amniocentesis performed (20 mL clear fluid) for cytogenetic analysis; patient discharged in stable condition |
| 19+6 weeks | Readmission with suspected PPROM. Laboratory results: WBC 20.37×10/μL, CRP 170 mg/L, ). Broad-spectrum antibiotics were initiated |
| 20+0 weeks | Intrauterine fetal death occurred; (male) |
| 20+3 weeks | Discharge in good condition; infection markers improving |
| Follow-up | CMA result: 1.4 Mb 17q12 deletion including ; maternal abdominal US: solitary renal cyst; paternal history: early-onset diabetes (MODY) |