25 March 2026
: Case report 
Adult-Onset Nesidioblastosis: A Challenging Diagnosis Revealed by Endoscopic Ultrasonography
Challenging differential diagnosis, Rare disease
Kristína Cmarková AEF 1, Peter Uhrík ADE 2*, Roman Kyčina EF 1, Lenka Nosáková DEG 2, Miroslav Pindura DEF 1, Martin Grajciar AEF 1, Michal Kalman DE 3, Peter Bánovčin EFG 2, Juraj Miklušica DE 1DOI: 10.12659/AJCR.951251
Am J Case Rep 2026; 27:e951251
Table 3 Histopathologic criteria for nesidioblastosis in adults [8].
| Major criteria | Minor criteria |
|---|---|
| Exclusion of an insulinoma (microscopically, macroscopically, and immunohistobiochemically) | Enlarged islets |
| Multiple β-cells with hyperchromatic, enlarged nuclei and clear cytoplasm | Increased number of islets |
| Islets with a normal spatial distribution of the different cell types | Lobulated islet structure |
| Endocrine cells without proliferative activity | Macronucleoli within β-cells |