27 March 2026
: Case report 
Reverse Takotsubo Syndrome Triggered by COVID-19–Associated Cytokine Storm: Unveiling a Novel Pattern of Myocardial Dysfunction in SARS-CoV-2 Infection
Unusual clinical course, Challenging differential diagnosis, Management of emergency care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Killen H. Briones-Claudett
ABCDEFG 1,2*, Killen H. Briones-Zamora ABCDEFG 3, Jaime Benites Solís ABCDEFG 2,4, María Antonieta Touriz Bonifaz ABCDEFG 5,6, Enny Berrus Zhumi ABCDEFG 2, Anahí D. Briones-Zamora ABCDEFG 2,3, Diana C. Briones Márquez ABCDEFG 2,4, Angela Germania Monserrate Romero ABCDEFG 5, Miguel Anderson Tayupanta Alban ABCDEFG 5, Hans Mautong ABCDEFG 7
DOI: 10.12659/AJCR.951623
Am J Case Rep 2026; 27:e951623
Table 1 Comparison between classical and reverse takotsubo cardiomyopathy (TTC).
| Feature | Classical TTC | Reverse TTC |
|---|---|---|
| Ventricular wall motion | Apical akinesia, basal hyperkinesia | Basal akinesia, apical hyperkinesia |
| Common triggers | Emotional or physical stress | Neurological disorders, infections |
| Demographic pattern | Postmenopausal women | Younger women |
| ECG findings | ST elevation (precordial leads) | ST depression, prolonged QT |
| Cardiac biomarkers | Mild-to-moderate elevation | Similar profile |
| Prognosis | Generally favorable | Generally favorable |