27 March 2026
: Case report 
Reverse Takotsubo Syndrome Triggered by COVID-19–Associated Cytokine Storm: Unveiling a Novel Pattern of Myocardial Dysfunction in SARS-CoV-2 Infection
Unusual clinical course, Challenging differential diagnosis, Management of emergency care, Rare disease, Educational Purpose (only if useful for a systematic review or synthesis)
Killen H. Briones-Claudett
ABCDEFG 1,2*, Killen H. Briones-Zamora ABCDEFG 3, Jaime Benites Solís ABCDEFG 2,4, María Antonieta Touriz Bonifaz ABCDEFG 5,6, Enny Berrus Zhumi ABCDEFG 2, Anahí D. Briones-Zamora ABCDEFG 2,3, Diana C. Briones Márquez ABCDEFG 2,4, Angela Germania Monserrate Romero ABCDEFG 5, Miguel Anderson Tayupanta Alban ABCDEFG 5, Hans Mautong ABCDEFG 7
DOI: 10.12659/AJCR.951623
Am J Case Rep 2026; 27:e951623
Table 3 Evolution of echocardiographic parameters in a patient with reverse takotsubo cardiomyopathy.
| Parameter | Day 4 (cardiac involvement) | Days 11–12 (discharge) | 6-Month follow-up |
|---|---|---|---|
| LVEF (%) | 45 | 55 | 63 |
| Global longitudinal strain (%) | −14 | −17 | Not evaluated |
| Diastolic function | Grade I | Grade I | Grade I |
| Left atrial volume (mL/m) | Not evaluated | Not evaluated | 33 |
| Tricuspid annular plane systolic excursion (mm) | Not evaluated | Not evaluated | 23 |
| Pulmonary artery systolic pressure (mmHg) | Not evaluated | Not evaluated | 16 |