24 April 2026
: Case report 
Diagnostic and Treatment Strategies for Adult Non-Ossifying Fibromas: A Case Report and Literature Review
Challenging differential diagnosis, Congenital defects / diseases
Zhibin Zhao BE 1, Jiawei Li C 1, Shaoke Wu ABEFG 1*DOI: 10.12659/AJCR.951665
Am J Case Rep 2026; 27:e951665
Table 2 Comparison of reports of large or adult-onset NOFs (non-ossifying fibromas).
| Study/case | Age lesion | Lesion size | Location clinical | Manifestations | Treatment modalities | Result | Key differences |
|---|---|---|---|---|---|---|---|
| This case | 28 years old | 55×34 mm | Proximal metaphysis of tibia | Painless lumps with rupture of the cortex | Abrasion + PMMA bone cement + steel plate | No recurrence 2 months after surgery, immediate weight-bearing | Adult mature bones have no potential for spontaneous regression |
| Herget et al (2016) []8 | Mainly children/adolescents | Mean 44±9 mm (fracture group) | Mainly lower limbs | Pathological fractures | Conservative/surgical varies | Natural History Research | Lesions in children can heal spontaneously, but adults cannot |
| Cai et al (2024) []7 | Adolescent | Large | Femur | Pathological fractures | Bone scraping + bone graft + steel plate internal fixation | Recovery is good after infection control | Surgical treatment requires attention to the risk of infection |
| Gill et al (2019) []4 | Adolescent (NF1-related) | Large | Proximal tibia | Pathological fractures | Conservative treatment | Healing | Lesions in children can heal spontaneously, but adults cannot |
| Parwaz et al (2020) []12 | Youths | – | Femoral neck | Pain/dysfunction | Free vascularized fibula grafting | Functional recovery | A special site (femoral neck) requires structural grafting |
| Bouaicha et al (2023) []9 | Adolescent | Multiple lesions | Multiple lesions | Aggressive manifestations | Surgery | No recurrence | Multiple lesions, differentiated from Jaffe-Campanacci syndrome |
| Cherix et al (2014) []11 | Adolescent | Large | Distal femur and proximal tibia | Pathological fractures | Steel plate is fixed inside | Healing | Jaffe-Campanacci syndrome with intellectual disability |