17 July 2026
: Case report 
Two Cases of Malaria-Associated Acute Respiratory Distress Syndrome and Severe Pulmonary Complications From Plasmodium falciparum in Tanzania
Unusual clinical course, Challenging differential diagnosis, Management of emergency care, Educational Purpose (only if useful for a systematic review or synthesis)
Hilary Chipongo EF 1*, Samina Chaki
AB 2, Esmail Sangey CD 1, Ronald Mclarty F 2, Rawya S.A. Baabde BEF 1, Kaushik Ramaiya ACE 3
DOI: 10.12659/AJCR.951737
Am J Case Rep 2026; 27:e951737
Table 2 Laboratory investigations in case 2 from admission to discharge.
| Test | Admission | ICU Day 2 | ICU Day 4 | ICU Day 6 |
|---|---|---|---|---|
| Hemoglobin | 15 | 14.6 | 12 | 12 |
| Malaria B/S (parasites/200 WBC) | 320/200 WBC | 400/200 WBC | 250/200 WBC | 80/200 WBC |
| Creatinine (60–120 μmol/L) | 324 | 620 | 622 | 380 |
| Urea (2.5–7.8 mmol/L) | 28 | 26 | 24 | 22 |
| Bilirubin, total (3.4–20.5 μmol/L) | 300 | 200 | 120 | 28 |
| Bilirubin, direct (0–5.1 μmol/L) | 260 | 180 | 80 | 40 |
| AST (10–40 U/L) | 120 | 110 | 100 | 80 |
| ALT (7–56 U/L) | 280 | 220 | 100 | 60 |
| Albumin (35–54 g/L) | 34 | 32 | 34 | 30 |
| C-reactive protein (<1 mg/dL) | 100 | 102 | 80 | 32 |
| Procalcitonin (<0.1 ng/mL) | 2 | 2.4 | 2 | 1.2 |
| Hepatitis B | Non-reactive | – | – | – |
| Hepatitis C | Non-reactive | – | – | – |
| HIV | Negative | – | – | – |
| Calcium (2.1–2.6 mmol/L) | 2.8 | 2.6 | 2.4 | 2.2 |
| Magnesium (0.7–1.05 mmol/L) | 1.7 | 2.21 | 1.98 | 2.8 |
| Sodium (135–145 mmol/L) | 130 | 132 | 1401 | 128 |
| Potassium (3.5–5.5 mmol/L) | 4.8 | 6.2 | 5.8 | 5.2 |
| Chloride (96–106 mmol/L) | 1011 | 1106 | 110 | 102 |