Hormone Receptor–Positive Encapsulated Papillary Carcinoma of the Breast With High-Grade Cytological Features: A Case Report With Invasive Heterogeneity

28 March 2026 : Case report Japan

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Unusual setting of medical care, Rare coexistence of disease or pathology

Yao Liu^{ABCDEF 1,2,3}, Akihiro Shioya

^{ABCD 1,3*}, Yusuke Haba^{BF 4}, Masafumi Inokuchi^{BF 4}, Sohsuke Yamada

^{AD 1,3}

DOI: 10.12659/AJCR.951744

Am J Case Rep 2026; 27:e951744

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Table 1 Results of immunohistochemistry and technical data in text.

Antibody	Different components	Result	Manufacturer	Species	Clone
ER	EPC with high-grade features	Diffuse positive	Roche Diagnostics	Rabbit	SP1
	High-grade invasive component
	Low-grade invasive component
PR	EPC with high-grade features	Diffuse positive	Roche Diagnostics	Rabbit	1E2
	High-grade invasive component
	Low-grade invasive component
HER2	EPC with high-grade features	1+, negative	Roche Diagnostics	Rabbit	4B5
	High-grade invasive component
	Low-grade invasive component
Ki-67	EPC with high-grade features	46.5%	DAKO	Mouse	MIB-1
	High-grade invasive component	36.5%
	Low-grade invasive component	5%
CK5/6	All components	Negative	DAKO	Mouse	D5/16 B4
p63	All components	Negative	Nichirei	Mouse	4A4
Syn	All components	Negative	Thermo	Rabbit	SP11
CgA	All components	Negative	DAKO	Mouse	DAK-A3
ER – estrogen receptor; PR – progesterone receptor; HER2 – human epidermal growth factor receptor 2; Ki-67 – Ki-67 proliferation index; CK5/6 – cytokeratin 5/6; p63 – tumor protein p63; Syn – synaptophysin; CgA – chromogranin A.

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