02 April 2026
: Case report 
Use of Apixaban for Venous Thromboembolism Prophylaxis in an Older Hemodialysis Patient After Total Knee Replacement: A Case Report
Unusual or unexpected effect of treatment, Clinical situation which can not be reproduced for ethical reasons
Abdalrhman H. Alanizi
AE 1,2*, Noof H. Alanazi BE 3, Aseel S. Bin Makhash BE 3, Rana H. Alotibi BE 3, Reem M. Qubaiban EF 4, Amal M. Badawoud E 2, Maad F. AlSaati D 5
DOI: 10.12659/AJCR.952509
Am J Case Rep 2026; 27:e952509
Table 1 Summary of pertinent laboratory trends.
| Test | Reference range | Sept 7 | Sept 8 | Sept 9 | Sept 10 | Sept 11 | Sept 12 | Sept 13 | Sept 14 |
|---|---|---|---|---|---|---|---|---|---|
| Complete blood count (CBC) | |||||||||
| Red cell count (×10/L) | 4.00–5.40 | 4.09 | 4.25 | 3.36 | 2.81 | 2.92 | 2.40 | 2.67 | 3.14 |
| Hemoglobin (g/L) | 120–160 | 126 | 127 | 103 | 86 | 88 | 73 | 83 | 95 |
| Hematocrit (L/L) | 0.360–0.540 | 0.369 | 0.371 | 0.305 | 0.257 | 0.271 | 0.22 | 0.247 | 0.280 |
| Reticulocyte (%) | 0.50–1.50 | 2.13 | 2.29 | 3.09 | 3.72 | 3.02 | 2.88 | 2.74 | |
| Platelet count (×10/L) | 150–400 | 222 | 193 | 164 | 120 | 165 | 166 | 246 | 284 |
| White cell count (×10/L) | 4–11 | 4.80 | 4.90 | 6.30 | 5.60 | 4.90 | 4.70 | 4.70 | 4.70 |
| Coagulation screen | |||||||||
| Prothrombin time (sec) | 10.70–13.60 | 11.00 | 11.2 | 11.5 | 13.4 | 10.8 | - | - | |
| INR | 0.80–1.20 | 0.92 | 0.94 | 0.97 | 1.13 | 0.90 | - | - | |
| APTT (s) | 25.10–36.50 | 29.50 | 29.7 | 29.7 | 108 | 33.5 | - | - | |
| Liver Function Test (LFT) | |||||||||
| Alkaline phosphatase (U/L) | 35–52 | 349 | 358 | ||||||
| Total bilirubin (μmol/L) | 5.0–21.0 | 4.5 | 4.7 | ||||||
| ALT (U/L) | 0–35 | 14 | 17 | ||||||
| AST (U/L) | 0–35 | 17 | 21 | ||||||
| Albumin (g/L) | 35–52 | 39 | 39 | ||||||
| Renal Function Test (RFT) | |||||||||
| Albumin (g/L) | 35–52 | 33 | 32 | ||||||
| Creatinine (μmol/L) | 58–96 | 580 | 364 | 512 | 182 | 347 | 323 | 486 | 406 |
| eGFR (mL/min/1.73 m) | >60 | 24 | 9 | ||||||
| Magnesium (mmol/L) | 0.77–1.03 | 0.67 | 0.75 | ||||||
| Phosphorus (mmol/L) | 0.81–1.45 | 0.72 | 1.03 | ||||||
| Uric acid (μmol/L) | 155–357 | 87 | 224 | ||||||
| Urea (mmol/L) | 2.8–7.2 | 3.5 | 11.4 | ||||||
| Calcium (mmol/L) | 2.20–2.65 | 2.20 | 1.96 | ||||||
| Electrolyte profile | |||||||||
| Sodium (mmol/L) | 136–144 | 133 | 128 | ||||||
| Potassium (mmol/L) | 3.5–5.1 | 3.6 | 5.3 | ||||||
| Chloride (mmol/L) | 101–109 | 101 | 96 | ||||||
| Corrected calcium (mmol/L) | 2.23–2.50 | 2.34 | 2.12 | ||||||
| Antibody screening | – | Negative | |||||||