04 August 2026
: Case report 
Right Ventricular Metastasis From Cervical Cancer Treated With Pembrolizumab-Containing Chemotherapy: A Case Report and Literature Review
Unusual clinical course
Chihiro Fukunaga ABCDEF 1, Kengo Hiranuma ABCDEF 1, Takashi Hirayama C 1, Emiko Yoshida
CD 1, Kazunari Fujino D 1, Sho Mizuno B 2, Hirofumi Inaba B 2, Harumi Saeki C 3, Yasuhisa Terao ACDEF 1*
DOI: 10.12659/AJCR.952931
Am J Case Rep 2026; 27:e952931
Table 1 Reported cases of cervical cancer with cardiac metastasis (n = 33).
| Case [Ref] | Age | Stage | Primary treatment | Other metastatic sites | Time to cardiac metastasis (months) | Secondary treatment | Regimen | Time to death from cardiac metastasis (months) |
|---|---|---|---|---|---|---|---|---|
| 1 []4 | 64 | IB | Op, CCRT | Longitudinal, abdominal wall | 7 | CCRT | Gemcitabine + carboplatin | 2 |
| 2 []4 | 32 | IIA | Op, CCRT | – | 15 | Op, CTx | Carboplatin + paclitaxel | 13 |
| 3 []4 | 28 | IIB | Op, RT | – | 10 | NA | – | 3 |
| 4 []4 | 28 | NA | Op, CCRT | Mediastinal lymph node | 16 | CTx | Cisplatin | 1 |
| 5 []4 | 32 | IIB | CTx | Pleura | 4 | Op | – | NA |
| 6 []4 | 36 | IB | Op, CTx | Lung, periaortic lymph nodes | 33 | CTx | Cisplatin + mitomycin C + vincristine | NA |
| 7 []4 | 37 | IIIB | CCRT | – | 3 | RT | – | > 8 |
| 8 []4 | 41 | IIB | Op, RT | – | 12 | CTx | Cisplatin + mitomycin C + vincristine | 5 |
| 9 []4 | 42 | IVB | RT | – | 6 | Op | – | NA |
| 10 []4 | 43 | IIB | RT | – | 5 | CTx | NA | NA |
| 11 []4 | 49 | IIIB | RT | – | 6 | CCRT | 5-fluorouracil + cisplatin | 7 |
| 12 []4 | 53 | IB | RT, Op | Lung | 14 | CCRT | 5-fluorouracil + cisplatin | 1 |
| 13 []4 | 49 | IVB | CCRT | Abdominal lymph node | 0 | CCRT | NA | 2.5 |
| 14 []4 | 57 | IIIB | CCRT | Periaortic lymph node | 10 | Op | – | 2 |
| 15 []4 | 58 | IB | Op, CTx | Periaortic lymph node | 43 | Op | – | 4 |
| 16 []4 | 63 | NA | Op, CCRT | – | 33 | Op | – | > 5 |
| 17 []4 | 64 | IIIB | RT | – | 7 | BSC | – | 0.3 |
| 18 []4 | 68 | IIIB | RT | – | 10 | Op, CTx | NA | 5 |
| 19 []4 | 78 | IIIB | RT | – | 5 | BSC | – | 1 |
| 20 []3 | 32 | IIA2 | Op, CCRT | – | 15 | Op, CTx | Carboplatin + paclitaxel | 13 |
| 21 []3 | 39 | IIA | Op, CTx | Left obturator lymph nodes | 21 | RT | – | 13 |
| 22 []3 | 22 | IVB | CCRT | – | 12 | Op, CCRT | NA | > 6 |
| 23 []3 | NA | IB2 | CCRT | Small intestine | 48 | Op, CCRT | NA | 8 |
| 24 []3 | 64 | IB | Op, CCRT | Abdominal muscle | 6 | CCRT | NA | 10 |
| 25 []3 | 42 | – | NA | – | 6 | Op | – | NA |
| 26 []3 | 63 | – | Op, CCRT | – | 396 | Op | – | > 5 |
| 27 []3 | 81 | – | Op, RT | – | 60 | BSC | – | 0.1 |
| 28 []3 | 57 | IIIB | CCRT | – | 10 | Op | – | 2 |
| 29 []3 | 68 | IIIB | NA | – | 24 | Op, CTx | NA | 5 |
| 30 []3 | 37 | IIIB | – | – | 0 | RT | – | > 8 |
| 31 | 51 | IB2 | Op | Ischium | 43 | CTx | Carboplatin + paclitaxel + pembrolizumab | – |
| 32 []6 | NA | IVB | CTx | Mediastinal lymph node, bilateral pleura | – | CCRT | Cisplatin + paclitaxel + atezolizumab | 16 |
| 33 []5 | 55 | IVB | CCRT | Spine | 3 | Op, CTx | Pembrolizumab | NA |
| Abbreviations: Op, operation; CCRT, concurrent chemoradiotherapy; RT, radiation therapy; CTx, chemotherapy; NA, not available; BSC, best supportive care. Note: Case 31 represents the present case. | ||||||||