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08 August 2020: Articles

Full Remission of Long-Term Premenstrual Dysphoric Disorder-Like Symptoms Following Resection of a Pituitary Adenoma: Case Report

Unusual clinical course, Unusual or unexpected effect of treatment

Guangrong Lu A , Tiana M. Shiver B , Spiros L. Blackburn B , William C. Yao B , Meenakshi B. Bhattacharjee B , Jay-Jiguang Zhu A*

DOI: 10.12659/AJCR.922797

Am J Case Rep 2020; 21:e922797

Figure 2. A proposed pathophysiological model for cyclic PMS/PMDD symptoms. The size of a normal functional pituitary gland changes during each menstrual cycle, but the extent of the change is limited or restricted by a NFPA (lesion is not drawn in the figure) or other types of space-occupying lesions. A distorted gland body or its stalk may reduce or even block the action of neurotransmitter(s) that originate from the hypothalamus or other anatomical connections. PMS/PMDD symptoms occur due to a delicate imbalance within the brain. When the size of the pituitary gland returns to baseline during the follicular phase, PMS/PMDD symptoms are also resolved while neurotransmitter transport is restored.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923