Figure 2. Histopathology. (A) Low-power magnification H&E photomicrographs of brain histology. Fragments of grey and white matter showing perivascular and parenchymal chronic inflammation, composed of lymphocytes, macrophages, and microglial cells. Rare multinucleated giant cells are seen (H&E ×10 objective). (B) Low-power magnification H&E photomicrographs of brain histology. Several variably sized aggregates of microglial cells forming microglial nodules are seen (H&E ×10 objective). (C) High-power magnification H&E photomicrographs of brain histology. Multiple rounded organisms are seen. The majority have a well-defined capsule with abundant granular/vacuolated cytoplasm, a round nucleus, and prominent central karyosome, consistent with amoebic trophozoites (blue arrows). Smaller ones have dark nuclei with a wrinkled and rather refractile outer capsule, consistent with amoebic cysts (red arrows) (H&E ×40 objective).