22 October 2020
: Case report 
An Autopsy Case of an Elderly Patient with Classic Hodgkin Lymphoma Presenting with a Plethora of Clinical Symptoms and Signs
Unusual clinical course, Mistake in diagnosis
Hiroshi Kobayashi1ABDEFG*, Ryouya Seki2BDE, Masuo Ujita3BDE, Kana Hirayama4BCD, Satoshi Yamada5BD, Riuko Ohashi6BD, Yoshiro Otsuki7BE, Takuya Watanabe8CDE, Tadashi Yoshino9CDFDOI: 10.12659/AJCR.926177
Am J Case Rep 2020; 21:e926177
Figure 5. (A) In situ hybridization of Epstein-Barr virus-encoded RNA demonstrated positivity in the nuclei of Hodgkin and Reed/Sternberg cells but not in the inflammatory cells. Magnification, ×400. (B) Many CD68-positive macrophages were intermingled with CD68-negative Hodgkin and Reed/Sternberg cells and small lymphocytes. Magnification, ×400. (C, D) Programmed death-ligand 1 (C) and interleukin-6 (D) were strongly positive for the tumor cells and inflammatory cells. Magnification, ×400.