04 June 2021
: Case report 
Xanthomatous Inflammatory Infiltrate Involving the Spleen: An Unusual Presentation of Erdheim-Chester Disease and Review of the Literature
Rare disease
Gioia Di Stefano12ABDEF*, Massimo Granai3BCDEF, Francesco Giudici4B, Giuliana Roselli5BCE, Stefano Lazzi1AE, Raffaella Santi2ABDEFDOI: 10.12659/AJCR.931060
Am J Case Rep 2021; 22:e931060
Figure 3. (A) Hematoxylin 7×. Splenic parenchyma with a preserved architecture and areas of hemorrhagic extravasation and an expanded red pulp. (B) Hematoxylin 60×. In the context of an expanded red pulp, a diffuse proliferation of histiocytes with a pale staining, foamy and finely granular cytoplasm and minimal nuclear pleomorphism was seen, which was occasionally associated with scattered, multinucleated cells, resembling Touton giant cells (black arrowhead). In the background, a mixed inflammatory infiltrate composed of plasma cells, small lymphocytes, and eosinophils was recognized.