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18 August 2021: Articles

A 55-Year-Old Japanese Man with Multiple Sclerosis Diagnosed with Disseminated Tuberculosis Identified by Liver Function Abnormalities: A Case Report

Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease, Adverse events of drug therapy, Educational Purpose (only if useful for a systematic review or synthesis)

Akio Miyasaka A* , Shinichirou Sato B , Tomoyuki Masuda C , Yasuhiro Takikawa A

DOI: 10.12659/AJCR.931369

Am J Case Rep 2021; 22:e931369

Figure 3. Clinical course. The diagnosis of disseminated tuberculosis (TB) was established. Thereafter, 4 anti-TB drugs were administered immediately. Twenty days after the start of the administration, the serum alanine aminotransferase (ALT) levels decreased to normal. After 1 month, streptomycin (SM) was replaced with ethambutol because of concerns about an auditory disorder. After 2 months of the 4-drug antituberculotic therapy, pyrazinamide and ethambutol (EB) were discontinued, but treatment with isoniazid and rifampin was continued. Approximately 6 months after the initiation of therapy, the patient’s liver function test results showed improvement. QFT – QuantiFERON test (interferon-γ releasing assay); US – ultrasonography; CT – computed tomography.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923