Toxic Epidermal Necrolysis Caused by Allopurinol: A Serious but Still Underestimated Adverse Reaction

Daniel Hoyer; Carlo Atti; Sebastian Nuding; Alexander Vogt; Daniel G. Sedding; Artjom Schott

doi:10.12659/AJCR.932921

11 October 2021 : Case report Germany

Toxic Epidermal Necrolysis Caused by Allopurinol: A Serious but Still Underestimated Adverse Reaction

Rare disease, Adverse events of drug therapy

Daniel Hoyer^1ACDEF*, Carlo Atti^1ABCDE, Sebastian Nuding^1E, Alexander Vogt^1E, Daniel G. Sedding^1E, Artjom Schott^1ABCDE

DOI: 10.12659/AJCR.932921

Am J Case Rep 2021; 22:e932921

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Figure 3. Zoomed microscopic view of skin biopsy showing necrotic basal and suprabasal epidermis with beginning of junctional separation, sparse lymphocytic infiltrates, apoptotic keratinocytes, and ectatic vessels in the upper corium.

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Toxic Epidermal Necrolysis Caused by Allopurinol: A Serious but Still Underestimated Adverse Reaction

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