02 November 2021
: Case report 
Glucocorticoids Induce Partial Remission of Focal Segmental Glomerulosclerosis but Not Interstitial Nephritis in COVID-19 Acute Kidney Injury in an APOL1 Low-Risk Genotype White Patient
Challenging differential diagnosis, Rare coexistence of disease or pathology
Piotr J. Nowak1ABCDEF*, Joanna Forycka2BCEF, Natalia Cegielska2BCEF, Karolina Harendarz2BCEF, Małgorzata Wągrowska-Danilewicz3BCD, Marian Danilewicz4BCD, Tomasz Płoszaj5BCD, Maciej Borowiec5CDG, Rafał Wlazeł6BCD, Michał Nowicki1DEGDOI: 10.12659/AJCR.933462
Am J Case Rep 2021; 22:e933462
Figure 2. First kidney biopsy: (A) segmental sclerosis and hyalinosis of the glomerular capillary tufts (PAS staining, ×200); (B) a small focus of collapsed capillary loops and overlying slight epithelial hypertrophy and hyperplasia in the Bowman space of one glomerulus (Jones’ methenamine-silver staining, ×200); (C) interstitial edema, severe degenerative changes of tubular epithelium and tubular microcysts, mild to moderate interstitial inflammation, composed of mononuclear leukocytes, some proximal tubular epithelial cells contained intracytoplasmic protein droplets positive for periodic-acid-Schiff (PAS staining, ×200). (D) The re-biopsy showed segmental sclerosis and hyalinosis of the glomerular capillary tuft, glomerular epithelial cells contained PAS – positive droplets (PAS staining, ×200).