16 August 2022>: Articles
Histiocytic Disorder Mimicking a Brain Tumor: A Report of 2 Rare Cases
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease
Frances Xiuyan Feng B , Negin Farsi B , Min Dai B , Areli K. Cuevas-Ocampo A , Diana M. Veillon A , James D. Cotelingam A*DOI: 10.12659/AJCR.935885
Am J Case Rep 2022; 23:e935885
Figure 2. Pathologic features of LCH. (A–D) H&E stains at different magnifications demonstrated brain parenchyma diffusely infiltrated by histocytes (hollow arrows; C, D) surrounded by extensive lymphoplasmacytic cells and abundant eosinophils (black arrows; C, D). The enlarged histocytes had abundant pale eosinophilic cytoplasm, elongated bean-shaped nuclei, distinct nucleoli, and nuclear grooves. (A: 20×; B: 100×; C: 200×; D: 400×). Histiocytes showed CD1a (E), CD68 (F), and S100 (G) positivity, as well as Langerin focally positivity (H).