16 August 2022: Articles
Histiocytic Disorder Mimicking a Brain Tumor: A Report of 2 Rare Cases
Challenging differential diagnosis, Diagnostic / therapeutic accidents, Management of emergency care, Rare disease
Frances Xiuyan Feng B , Negin Farsi B , Min Dai B , Areli K. Cuevas-Ocampo A , Diana M. Veillon A , James D. Cotelingam A*DOI: 10.12659/AJCR.935885
Am J Case Rep 2022; 23:e935885
Figure 4. Pathologic features of RDD. (A–D) Histologically, the brain parenchyma was diffusely infiltrated by large histiocytes admixed with abundant plasma cells and lymphocytes. Emperipolesis was present (black arrows: B, C). Some of the plasma cells contained Russell bodies (black arrow: D). (A: 40×; B: 200×; C, D: 400×). The immunohistochemical profile showed CD68 (E) and S100 (F) reactivity in lesional histocytes, while CD1a (G) was negative. CD138 highlighted polyclonal plasma cells (H) without light chain restriction on ISH (I: kappa ISH and J: Lambda ISH).