Thrombotic Microangiopathy Secondary to Systemic Sclerosis with Severe Complement Activation Not Responsive to Eculizumab: A Case Report

Masahiko Nakamura; Tomohiro Abe; Hidenobu Ochiai

doi:10.12659/AJCR.936116

07 June 2022 : Case report Japan

Thrombotic Microangiopathy Secondary to Systemic Sclerosis with Severe Complement Activation Not Responsive to Eculizumab: A Case Report

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Unexpected drug reaction

Masahiko Nakamura^1ABCDEF*, Tomohiro Abe

^1ABCDE, Hidenobu Ochiai^1ACDE

DOI: 10.12659/AJCR.936116

Am J Case Rep 2022; 23:e936116

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Figure 1. The patient’s hand and sole at (A) admission and (B) on day 12. (A) The patient’s hand exhibited purpura that extended to the tips as well as skin sclerosis on fingertips. (B) The ischemic lesion on his fingers were exacerbated and purpura on his sole revealed.

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Thrombotic Microangiopathy Secondary to Systemic Sclerosis with Severe Complement Activation Not Responsive to Eculizumab: A Case Report

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