29 June 2022: Articles
Acute Hepatitis with Positive Autoantibodies: A Case of Natalizumab-Induced Early-Onset Liver Injury
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Unexpected drug reaction, Educational Purpose (only if useful for a systematic review or synthesis)
Marlone Cunha-Silva ** , Priscilla Brito Sena de Moraes * , Pedro Rodrigues de Carvalho A , Larissa Bastos Eloy da Costa B , Guilherme Rossi Assis-Mendonça B , Cristina Alba Lalli B , Gisele Conte Alves Fernandes B , Fernanda Bocchi Monteiro B , Gustavo Manginelli Lamas B , Alfredo Damasceno B , Daniel Ferraz de Campos Mazo C , Tiago Sevá-Pereira DDOI: 10.12659/AJCR.936318
Am J Case Rep 2022; 23:e936318
Figure 2. (A) Low magnification of liver parenchyma, exhibiting initial architectural distortion with pericellular fibrosis and delicate septa (arrows), due to recent extracellular matrix deposition (Masson trichrome stain, 4×). (B) Medium magnification of portal area with an acute and chronic infiltrate, ductular reaction (arrow head), and prominent cholestasis (*). Ballooning degeneration and apoptotic hepatocytes (arrow) and spotty inflammation are seen in the adjacent lobule (H&E stain, 10×). (C) Mild epithelial damage of the bile duct (arrow) without ductopenia (H&E stain, 10×).