Logo American Journal of Case Reports

Call: 1.631.629.4328
Mon-Fri 10 am - 2 pm EST

Contact Us

Logo American Journal of Case Reports Logo American Journal of Case Reports Logo American Journal of Case Reports

29 June 2022: Articles

Acute Hepatitis with Positive Autoantibodies: A Case of Natalizumab-Induced Early-Onset Liver Injury

Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment, Diagnostic / therapeutic accidents, Unexpected drug reaction , Educational Purpose (only if useful for a systematic review or synthesis)

Marlone Cunha-Silva ** , Priscilla Brito Sena de Moraes * , Pedro Rodrigues de Carvalho A , Larissa Bastos Eloy da Costa B , Guilherme Rossi Assis-Mendonça B , Cristina Alba Lalli B , Gisele Conte Alves Fernandes B , Fernanda Bocchi Monteiro B , Gustavo Manginelli Lamas B , Alfredo Damasceno B , Daniel Ferraz de Campos Mazo C , Tiago Sevá-Pereira D

DOI: 10.12659/AJCR.936318

Am J Case Rep 2022; 23:e936318

Figure 2. (A) Low magnification of liver parenchyma, exhibiting initial architectural distortion with pericellular fibrosis and delicate septa (arrows), due to recent extracellular matrix deposition (Masson trichrome stain, 4×). (B) Medium magnification of portal area with an acute and chronic infiltrate, ductular reaction (arrow head), and prominent cholestasis (*). Ballooning degeneration and apoptotic hepatocytes (arrow) and spotty inflammation are seen in the adjacent lobule (H&E stain, 10×). (C) Mild epithelial damage of the bile duct (arrow) without ductopenia (H&E stain, 10×).

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923