Figure 1. Bone marrow aspirate and trephine photomicrographs showing features of chronic parvovirus-B19 pure red cell aplasia in a 69-year-old HIV-1-positive man. (A) Bone marrow aspirate showing characteristic giant pronormoblasts featuring ground-glass changes, vacuolation, and viral inclusions with impaired erythropoiesis. Giemsa-Wright. Magnification ×400. (B) Bone marrow aspirate showing a giant, multinucleated proerythroblast and impaired red cell production. Giemsa-Wright. Magnification ×600. (C) Bone marrow trephine showing the absence of erythroid islands with normal granulocyte differentiation. Hematoxylin and eosin (H&E). Magnification ×400. (D) Bone marrow trephine showing characteristic giant proerythroblasts with viral inclusions, vacuolation, and pure red cell aplasia. H&E. Magnification ×600.