17 January 2023: Articles
A 12-Year-Old Girl with Juvenile Granulosa Cell Tumor of the Ovary, Presenting with Adolescent Hyperprolactinemia, Galactorrhea, and Amenorrhea
Challenging differential diagnosis, Rare disease
Hyunsoo Park B , Corban P. Goodman E , Steven L. Raymond B , Andrew Sundin B , Faraz A. Khan E , Andrei Radulescu ADOI: 10.12659/AJCR.938249
Am J Case Rep 2023; 24:e938249
Figure 4. Photomicrographs of the diagnostic histopathology and immunohistochemistry of juvenile granulosa cell tumor of the ovary in a 12-year-old girl. (A) The histology of juvenile granulosa cell tumor shows cords of cohesive cells with eosinophilic cytoplasm and irregular cell nuclei, but no mitoses or necrosis. Hematoxylin and eosin (H&E). Magnification ×60. (B) Low-power histology of juvenile granulosa cell tumor shows sheets of tumor cells and some cystic areas. Hematoxylin and eosin (H&E). Magnification ×20. (C) Immunohistochemistry for calretinin shows positive brown staining of the cytoplasm of the tumor cells. Magnification ×40. (D) Immunohistochemistry for inhibin A shows positive brown staining of the nuclei of the tumor cells. Magnification ×60.