11 March 2023>: Articles
Heidenhain Variant of Sporadic Creutzfeldt-Jakob Disease with a Variety of Visual Symptoms: A Case Report with Autopsy Study
Challenging differential diagnosis, Rare disease
Yoshio Hisata A , Shun Yamashita A* , Masaki Tago A , Motoi Yoshimura C , Tomotaro Nakasima A , Tomoyo M. Nishi A , Yoshimasa Oda A , Hiroyuki Honda C , Shu-ichi Yamashita DDOI: 10.12659/AJCR.938654
Am J Case Rep 2023; 24:e938654
Figure 4. Microscopic findings of brain tissue. (A) Hematoxylin and eosin staining of the medial basal aspect of the right occipital lobe showed neuronal loss, spongiform change of the cortex, and neuropil rarefaction. (B) Immunostaining for prion protein with 3F4 antibody to the same area showed deposits of the synaptic type of prion protein. (C) Immunohistochemical staining for glial fibrillary acidic protein showed hypertrophic astrocytes.