Paraneoplastic Neuromyelitis Optica Spectrum Disorder: A Rare Case of Advanced Breast Cancer with Intractable Nausea and Vomiting

Daisuke Miyagishima; Toshiharu Anezaki; Akiyo Fukuda; Hiroki Watanabe; Maki Hata; Masanobu Eguchi

doi:10.12659/AJCR.941808

07 November 2023 : Case report Japan

Paraneoplastic Neuromyelitis Optica Spectrum Disorder: A Rare Case of Advanced Breast Cancer with Intractable Nausea and Vomiting

Challenging differential diagnosis, Rare coexistence of disease or pathology

Daisuke Miyagishima

^1ABEF*, Toshiharu Anezaki^2CD, Akiyo Fukuda^3BD, Hiroki Watanabe^3BD, Maki Hata^4D, Masanobu Eguchi^5BD

DOI: 10.12659/AJCR.941808

Am J Case Rep 2023; 24:e941808

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Figure 6. Histopathological features of breast tumor specimens obtained with core needle biopsy. (A) Tumor cells invade the fibrous stroma, suggesting scirrhous-type invasive ductal carcinoma (hematoxylin/eosin staining, ×400). (B) Immunohistochemical staining demonstrates abundant aquaporin-4 expression in tumor cells with negative immunoreactivity observed in the normal breast parenchyma (Anti-AQP4; Atlas Antibodies, Stockholm, Sweden; ×400).

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Paraneoplastic Neuromyelitis Optica Spectrum Disorder: A Rare Case of Advanced Breast Cancer with Intractable Nausea and Vomiting

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