Transformation of Severe Aplastic Anemia into Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Rare Case Report

Qianqian Wang; Hong Xu; Wei Yu; Lingjie Sun; Hongguo Zhao; Xue Shi

doi:10.12659/AJCR.943801

18 April 2024 : Case report China (mainland)

Transformation of Severe Aplastic Anemia into Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Rare Case Report

Rare disease

Qianqian Wang^1ABCDEFG, Hong Xu^1ABCD, Wei Yu^1BC, Lingjie Sun^1BC, Hongguo Zhao^1BC, Xue Shi^1ADF*

DOI: 10.12659/AJCR.943801

Am J Case Rep 2024; 25:e943801

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Figure 1. (A) Bone marrow smear showed hypoplasia, and no megakaryocytes were seen (Jenner-Giemsa stain, 400×). (B) Bone marrow iron stain was positive (++; iron stain, 200×). (C, D) Bone marrow biopsy showed about 10% cellularity and most of the hematopoietic tissue was replaced by adipose tissue (hematoxylin-eosin stain, 200× and 400×, respectively).

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Transformation of Severe Aplastic Anemia into Donor Cell Leukemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Rare Case Report

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