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20 January 2026 : Case report  China

Successful Long-Term Remission in Infantile Acute Leukemia Treated With Chemotherapy and Blinatumomab: A Case Report

Unusual or unexpected effect of treatment

Qiuying He E 1, Bin Zhang A 1, Shuang Li A 1, JiaWei Yang A 1, Liangchun Hao A 1*

DOI: 10.12659/AJCR.950502

Am J Case Rep 2026; 27:e950502

Figure 1 There is significant bone marrow growth (magnification 1000×). Anucleate cells to nucleated cells ratio is 1000: 220. The granulocyte series accounts for 1.2%, while the erythroid series accounts for 5.6%. The granulocyte to erythroid ratio is 0.21: 1. The granulocyte series exhibits drastically decreased proliferation. Red cell series hyperplasia has diminished, and no noticeable morphological abnormalities have been found. The lymphoid system exhibited aberrant hyperplasia, with big cells (91.2%) in round or oval shape with uneven borders. The cytoplasm was sparse and sky-blue. The nuclei were distorted, displaying obvious pits, folds, and indentations. The nuclear chromatin was sparse and fine-grained, with 1 to 3 nucleoli visible in certain cells. The bone marrow smear contained 25 megakaryocytes. There were no typical megakaryocytes forming plates throughout the smear. Small clusters of platelets were occasionally seen.

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American Journal of Case Reports eISSN: 1941-5923
American Journal of Case Reports eISSN: 1941-5923