19 December 2025
: Case report 
Primary Orbital Lymphoma Manifesting as Increased Intraocular Pressure: A Case Report
Unusual clinical course, Challenging differential diagnosis, Unusual or unexpected effect of treatment
Miaomiao Sun AEG 1, Zhaohui Xiong F 1, Yincong Xu B 1, Zhongyou Zhou F 1, Jiale Wu BC 1, Jiangzhou Han BC 1, Lina Zhao A 1*DOI: 10.12659/AJCR.951048
Am J Case Rep 2025; 26:e951048
Figure 3 At low-power magnification (4×), a dense, infiltrative lesion with a diffuse growth pattern was observed. The lesion lacked distinct margins and invaded adjacent tissues, consistent with a high-grade neoplasm. No organized structures such as follicles or glands were present. At high-power magnification (40×), clusters of large, atypical lymphoid cells were visible, characterized by irregular nuclear contours, prominent nucleoli, and dispersed chromatin. Numerous mitotic figures indicated rapid cellular proliferation. The absence of differentiation toward other hematologic lineages further supported a diagnosis of lymphoid malignancy.